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Table 4 Univariable and multivariable Cox regression analysis for death

From: Association between body fat decrease during the first year after diagnosis and the prognosis of idiopathic pulmonary fibrosis: CT-based body composition analysis

 

Univariable analysis

Multivariable analysis (model 1)

Multivariable analysis (model 2)

Multivariable analysis (model 3)

Variables

Hazard ratio

P value

Hazard ratio

P value

Hazard ratio

P value

Hazard ratio

P value

Age (year)

1.039 (1.018, 1.060)

< 0.001

1.064 (1.041, 1.088)

< 0.001

    

Sex (reference: female)

1.399 (0.931, 2.102)

0.107

1.808 (0.990, 3.300)

0.054

    

BMI (kg/m2)

0.966 (0.910, 1.024)

0.244

0.892 (0.837, 0.950)

< 0.001

0.882 (0.826, 0.942)

< 0.001

  

Change in BMI during the first year post-diagnosis (kg/m2)

0.931 (0.809, 1.071)

0.319

    

1.011 (0.875, 1.170)

0.878

Smoking history (reference: never smoker)

1.311 (0.912, 1.884)

0.143

1.180 (0.706, 1.972)

0.528

1.137 (0.779, 1.660)

0.506

  

Antifibrotics (reference: no use)

0.985 (0.674, 1.439)

0.937

      

Baseline GAP score

1.747 (1.483, 2.058)

< 0.001

  

1.667 (1.401, 1.984)

< 0.001

  

Baseline FVC (% predicted)

0.981 (0.970, 0.992)

0.001

0.984 (0.972, 0.997)

0.013

    

Baseline DLCO (% predicted)

0.981 (0.971, 0.991)

< 0.001

0.978 (0.967, 0.990)

< 0.001

    

FVC decline ≥ 5% during the first year post-diagnosis (% predicted) (reference: FVC decline < 5%)

2.113 (1.507, 2.962)

< 0.001

    

2.070 (1.464, 2.927)

< 0.001

DLCO decline ≥ 10% during the first year post-diagnosis (% predicted) (reference: DLCO decline < 10%)

2.179 (1.506, 3.151)

< 0.001

    

2.144 (1.478, 3.109)

< 0.001

Baseline pulmonary artery diameter (mm)

1.080 (1.036, 1.126)

< 0.001

1.079 (1.028, 1.132)

0.002

1.084 (1.033, 1.139)

0.001

  

IPF extent on baseline CT (%)

1.023 (1.011, 1.035)

< 0.001

1.010 (0.995, 1.026)

0.192

1.018 (1.004, 1.032)

0.014

  

Muscle area at T12-L1 on baseline CT (cm2) (reference: upper three quartiles)

1.105 (0.752, 1.623)

0.608

      

Change in muscle area at T12-L1 during the first year post-diagnosis (cm2) (reference: upper three quartiles)

1.144 (0.779, 1.680)

0.491

      

Fat area at T12-L1 on baseline CT (cm2) (reference: upper three quartiles)

1.092 (0.736, 1.619)

0.659

      

Change in the fat area at T12-L1 during the first year post-diagnosis (cm2) (reference: upper three quartiles)

1.626 (1.131, 2.337)

0.009

1.594 (1.077, 2.36)

0.020

1.513 (1.025, 2.234)

0.037

1.488 (1.021, 2.167)

0.038

  1. BMI: body mass index; GAP: gender, age, and physiologic variables; FVC: forced vital capacity; DLCO: diffusing capacity of carbon monoxide; IPF: idiopathic pulmonary fibrosis
  2. Model 1 is with baseline clinical-radiological variables; Model 2 is with baseline clinical-radiological variables including GAP score; Model 3 is with variables obtained at 1-year follow-ups
  3. Multivariable Cox proportional hazard regression analysis was performed with variables with P-values < 0.2 in the univariable analysis and BMI (both results at baseline and change in follow-up) since this factor was reported as a poor prognostic factor in prior study
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Respiratory Research

ISSN: 1465-993X

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