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Table 4 Cox regression analysis for risk factors of mortality in participants with interstitial lung abnormality*

From: Interstitial lung abnormality evaluated by an automated quantification system: prevalence and progression rate

Characteristics

Unadjusted analysis

Multivariable analysis

HR (95% CI)

P-value

HR (95% CI)

P-value

Age, years

1.085 (1.037–1.137)

< 0.001

1.062 (1.012–1.115)

0.015

Male

1.976 (0.582–6.707)

0.275

-

-

Ever-smokers

3.306 (0.974–11.222)

0.055

3.802 (1.044–13.842)

0.043

BMI, kg/m2

1.003 (0.864–1.165)

0.967

-

-

WBCs, ×103/µL

1.226 (1.042–1.443)

0.014

-

-

Hgb, g/dL

0.838 (0.637–1.103)

0.208

-

-

Platelet, ×103/µL

0.999 (0.990–1.007)

0.739

-

-

ESR, mm/h

1.044 (1.022–1.066)

< 0.001

1.036 (1.005–1.067)

0.021

Glucose, mg/dL

1.008 (0.990–1.026)

0.401

-

-

HbA1c, %

1.476 (0.997–2.187)

0.052

-

-

Total cholesterol, mg/dL

0.987 (0.974–0.999)

0.041

-

-

Triglyceride, mg/dL

1.000 (0.995–1.006)

0.916

-

-

HDL, mg/dL

0.942 (0.902–0.984)

0.007

-

-

LDL, mg/dL

0.990 (0.977–1.004)

0.175

-

-

Protein, g/dL

0.498 (0.165–1.506)

0.217

-

-

Albumin, g/dL

0.061 (0.020–0.193)

< 0.001

0.173 (0.040–0.738)

0.018

BUN, mg/dL

1.070 (0.965–1.186)

0.202

-

-

Creatinine, mg/dL

2.822 (0.553–14.401)

0.212

-

-

FVC, predicted %

0.960 (0.919–1.003)

0.069

-

-

FEV1, predicted %

0.981 (0.945–1.019)

0.324

-

-

FEV1/FVC, %

0.805 (0.709–0.912)

0.001

-

-

  1. HR, hazard ratio; CI, confidence interval; BMI, body mass index; WBCs, white blood cells; Hgb, haemoglobin; ESR, erythrocyte sedimentation rate; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; BUN, blood urea nitrogen; FVC, forced vital capacity; FEV1, forced vital capacity in 1 s; *evaluated on the basis of follow-up chest computed tomography (CT) images