Fig. 2
From: Circular RNAs and their roles in idiopathic pulmonary fibrosis
Biogenesis, trafficking, degradation, and biological functions of circRNAs. CircRNAs arise from pre-mRNA by lariat intermediate and direct back-splicing methods. After biogenesis, circRNAs are transported into cytoplasm by DDX39B/DDX39A, NF-90/NF-110 or through m6A. CircRNAs can undergo degradation in the cytoplasm upon the endonucleolytic cleavage endonucleolytic cleavage by RNase P, RNase L and miR-671 or structure-mediated degradation by UPF1 and G3BP1. CircRNAs can function as (A)- regulator of parenteral gene expression, (B)- miRNA sponge, (C)- protein sponge, (D) -protein scaffold, and (E)- template for translation. (Created with BioRender.com)