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Table 2 SSc-ILD, radiologic and histopathologic features and correlations

From: The role of lung biopsy for diagnosis and prognosis of interstitial lung disease in systemic sclerosis: a systematic literature review

Ref.

LBx cases/TOTAL SSc-ILD cases (%)

Lung biopsyNSIP

Lung biopsy: cellular NSIP

Lung biopsy: fibrosing-NSIP

Lung biopsy: UIP

Lung biopsy. Other

N of cases with HRCT data

HRCT: NSIP/UIP/other

HRCT concordant with histopathology NSIP/UIP

HRCT discordant (HRCT -> histopathology)

Fischer, Chest 2008

22/27 (82%)

14/22 (64%)

1/22(4%)

13/22(60%)

8/22(36%)

-

9

8/1/0

5/1

3 NSIP -> UIP

Kim, Sarcoidosis VDLD 2002

19/19 (100%)

13/19 (68%)

2/19 (10%)1

11/19 (58%)

5/19(26%)

1 end stage lung (hcc only)

18

15/3/0

13/3

2 NSIP -> UIP

De Souza, Respiration 2009

28/28 (100%)

19/28 (68%)2

-

-

1/28 (3%)

6 CLF; 1 PH; 1 RB-ILD

19

183/1/0

183/0

1 UIP -> NSIP4

Bouros, AJRCCM 2022

80/80 (100%)

62/80 (77.5%)

15/80 (19%)

47/80 (59%)

6/80 (7.5%)

6 ESL; 4 RB-ILD, 1 sarcoidosis, 1 OP

-

-

-

-

de Carvalho, Histopathology 2008

18/18 (100%)

18/18 (100%)

-

18/18 (100%)

-

-

-

-

-

-

Felicio, Lung 2007

10/10 (100%)

10/10 (100%)

-

10/10 (100%)

-

-

-

-

-

-

Christmann, Arthritis and Rheum 2014

21/21 (100%)

16/21 (76%)

-

-

-

5 CLF

-

-

-

-

Domiciano, Clin Rheum 2011

24/24 (100%)

18/24 (75%)

14/24 (58%)

4/24 (16%)

 

4 CLF; 1 PH; 1 RB-ILD

-

-

-

-

Yamakawa, PLoS One 2016

32/72 (44%)

20/32 (62%)

-

20/32 (62%)

1/32 (3%)

11 unclassifiable

72

48/10/145

-

-

Parra, Brazilian J Med and Biol Res 2013

23/23 (100%)

23/23 (100%)

11/23 (48%)

12/23 (52%)

-

-

-

-

-

-

Harrison, AJRCCM 1991

34/34 (100%)

-

-

-

-

34/346

-

-

-

-

Franco De Carvalho, Respiration 2008

18/18 (100%)

18/18 (100%)

-

-

-

-

-

-

-

-

Xiao, Rheum Dis 2018

25/25 (100%)

-

-

-

-

-

-

-

-

-

  1. Abbreviations. ILD: interstitial lung disease. HRCT: high resolution computed tomography. ESL: end stage lung; hcc: honeycomb changes; CLF: centrilobular fibrosis; PH: pulmonary hypertension; RB-ILD: respiratory bronchiolitis interstitial lung disease; OP: organizing pneumonia; NSIP: non specific interstitial pneumonia; UIP: usual interstitial pneumonia
  2. (1) All cases were mixed NSIP (cellular and fibrotic), no cases of pure cellular NSIP were reported in this study. (2) 16/19 NSIP cases showed coexistent centrilobular fibrosis. (3) all 18 NSIP cases showed pure ground glass on HRCT, except one with reticulations. (4) one case with HRCT reticulations was misread by the radiologist as UIP, pathology confirmed NSIP. (5) other: unclass N = 10; PPFE N = 4. (6) this study didn’t define histopthologic patterns but described all cases as mixed fibrosis and inflammation similar to cryptogenic fibrosing alveolitis, nowadays defined idiopathic pulmonary fibrosis