Performance | FEV1% predicted | FEV1/FVC | FEF25 − 75 (L) | VEmph |
---|
Adjusted R2 | 0.516 | 0.602 | 0.526 | 0.778 |
SE | 15.8 | 0.084 | 0.331 | 0.057 |
Age (yrs) | 0.085** | 0.021 (0.06) | -0.184** | 0.035** |
Sex (M/F) | Â | 0.018 (0.08) | -0.283** | -0.035** |
BMI (kg/cm2) | -0.110** | 0.033* | 0.024** | -0.232** |
Smoking (Pack Years) | -0.046** | -0.013 (0.22) | -0.051** | -0.015 (0.06) |
CT vendor | Â | Â | Â | 0.111** |
Race | Â | 0.113** | -0.033* | Â |
VNorm | 0.727** | 0.668** | 0.688** | -1.01** |
VfSAD | 0.065* | Â | 0.138** | -0.408** |
χNorm |  | -0.120** | 0.134** | 0.150** |
χfSAD | 0.106** |  | 0.175** | 0.118** |
- Notes Multivariable regression modelling using volume density (V) and Euler-Poincaré Characteristic (χ) for PRM-derived Normal and fSAD (introduced stepwise) to model pulmonary function testing measures in the COPD subset. Each column presents results for a different regression model. FEV1, forced expiratory volume in one second; FVC, forced vital capacity; FEF25 − 75, forced mid-expiratory flow; Emph, emphysema; SE, standard error of the estimate; BMI, body mass index; Norm, Normal; fSAD, functional small airways disease. Model performance is reported as adjusted R2 and standard error of the estimate. Feature association is reported as standardized beta coefficients (β); cells for stepwise variables removed from final model. All regression models were controlled for age, sex, race, BMI, pack years and CT vendor. P values ≥ 0.01, < 0.01 and ≥ 0.001, and < 0.001 are presented as values in parentheses, *, and **, respectively