Fig. 6

PRDX3 overexpression induces metabolic reprogramming in RAW 264.7 cells. (A) QC, (B) PCA and (C) PLS-DA comparing subjects from Adv-NC and Adv-PRDX3 groups. (D) The structural composition of the metabolites in Adv-NC and Adv-PRDX3 group. (E) The abundance of Top 20 metabolites in Adv-NC and Adv-PRDX3 group. (F) Volcano of 25 metabolites in Adv-NC and Adv-PRDX3 group. (G, H) The levels of Citrate, α-KG, Succinate, TPP, cis-Aconitate, GTP, β-D-F6P, F1,6P and DHAP detected in RAW 264.7 cells after PRDX3 overexpression. (I) Schematic diagram of Glycolysis and the TCA cycle. ^*P < 0.05, vs the Adv-NC group