Table 2 Adverse drug reactions and implicated antibiotics
Adverse Drug Reactions | Tolerant | Intolerant |
|---|---|---|
Common Terminology Criteria for Adverse Events Grade 3 or greater1 (Total) | 3 (2%) | 13 (13%) |
Gastrointestinal symptoms | 34 (23%) | 58 (55%) |
Rash | 4 (3%) | 9 (8.5%) |
Fatigue | 5 (3%) | 23 (22%) |
Cough, dysphonia, or bronchospasm | 4 (3%) | 4 (4.7%) |
Visual disturbance | 2 (1%) | 11 (10%) |
Auditory disturbance | 1 (0.7%) | 5 (5%) |
Acute kidney injury | 0 | 4 (4%) |
Hemoptysis | 0 | 1 (1%) |
Anaphylaxis | 0 | 1 (1%) |
Other | 6 (4%) | 8 (8%) |
Implicated Antibiotic | Â | Â |
Macrolides | 12 (8%) | 21 (19%) |
Rifamycins | 4 (3%) | 46 (43%) |
Ethambutol | 3 (2%) | 22 (20%) |
Amikacin liposomal inhalation suspension | 4 (3%) | 11 (10%) |
Parenteral Amikacin | 0 | 5 (5%) |