Clinical characterization and outcomes of impulse oscillometry-defined bronchodilator response: an ECOPD cohort-based study

Table 3 Univariate and multivariable linear regression models of outcomes in overall participants with and without IOS-BDR.

Outcome *	Group	Unadjusted			Adjusted ^†
Outcome *	Group	Mean difference	95% CI	P Value	Mean difference	95% CI	P Value
CAT scores (n = 465)	Without IOS-BDR	Reference	-		Reference	-
CAT scores (n = 465)	With IOS-BDR	1.33	0.56, 2.10	0.001	1.20	0.44, 1.97	0.002
LAA_− 950 (n = 327)	Without IOS-BDR	Reference	-		Reference	-
LAA_− 950 (n = 327)	With IOS-BDR	1.63	0.29, 2.97	0.017	2.04	0.81, 3.28	0.001
LAA_− 856 (n = 327)	Without IOS-BDR	Reference	-		Reference	-
LAA_− 856 (n = 327)	With IOS-BDR	8.28	3.14, 13.43	0.002	10.42	6.01, 14.84	< 0.001

CAT, COPD Assessment Test; Reference group = Without IOS-BDR.; LAA_− 950, low-attenuation area of the lung with attenuation values below − 950 Hounsfield units; HU, Hounsfield Unit; LAA_− 856, low-attenuation area of the lung with attenuation values below − 856 Hounsfield units;
* Linear regression model
† Adjusted for age, sex, BMI, smoking status, pack-years, family history of respiratory diseases, occupation exposure, biomass exposure, history of asthma

ISSN: 1465-993X