Fig. 7
From: A novel quinoline with airway relaxant effects and anti-inflammatory properties
Effect of pre-incubation with RCD405 on LPS induced NF-κB signaling, metablic (reductase) activity, and LDH release in THP1-Blue cells. A NF-κB signaling in LPS-stimulated cells in the absence or presence of RCD405 at the indicated concentration. B Reductase-activity as measured by an MTT assay in THP1-Blue cells incubated with RCD405 at the indicated concentrations for 24 h. C Cytotoxicity as measured by release of LDH in THP1-Blue cells incubated with the indicated concentrations of RCD405 for 24 h. Statistical comparisons were performed using a one-way ANOVA followed by a Dunnett’s post-hoc test, (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001). Experiments were performed in triplicates and repeated three times (n = 9)