Fig. 1
From: PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap
Alveolar macrophages were the major cell types in patients with ACO. A, A total of 12 cell clusters were identified within the scRNA-Seq dataset generated from human lung tissues of patients with ACO (n = 1) and without ACO (n = 2). B, Cell clusters in (A) were further annotated as different cell types by using the SingleR algorithm. C, Heatmap represents the top-ranking differentially expressed genes for each cell type in (B). D, Relative percentage of each cell type in ACO and controls. E, A total of seven clusters were identified within monocytes/macrophages by using the Leiden algorithm. F, Cell clusters in (E) were further annotated as different sub-types of monocytes/macrophages. G, Heatmap represents the top-ranking differentially expressed genes for each cell type in (F). ACO: asthma-COPD overlap. Chi-Square tests were performed for the comparisons of category variables