Fig. 3

A lower prevalence of senescence in patients with severe asthma in an IMSA dataset. A, Identification of stable and meaningful clusters by repeated consensus clustering analysis with different values of k (from 2 to 5) within a IMSA dataset. B, Consistent and stable cellular senescence clusters identified by Cumulative Distribution Function (CDF). C, Two clusters were assigned senescence low and high group according to the ssGSEA SenMayo Senescence score. D-F, Relative expression of senescence markers CDKN1A (p21, D), CDKN2A (p16, E), and proliferation marker MKI67 (F) in senescence clustering low and high group. G, Relative percentage of health control (HC, n = 5), mild/moderate asthma patients (MMA, n = 17), and severe asthma (SA, n = 16) participants in senescence clustering low and high group. Fisher’s Exact test was performed for the comparisons of category variables. Wilcox rank sum tests were used for the comparison of numerical variables between 2 groups. A p < 0.05 was considered as statistical significance