Fig. 4
From: PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap
Airway CD206+macrophages show a lower prevalence of senescence but increased cytokines. A, Density scatter plots showed the distribution of relative expression of markers for cell type annotation. B, A total of 7 different cell clusters annotated using a combination of surface marker genes. C, Relative percentage of each cell type in senescence clustering low and high group. D, Levels of cytokines in BAL fluids in senescence clustering low and high group of the IMSA cohort. E, Heatmap represents cytokine expression in CD206+ macrophages of senescence clustering low and high group. Variables. Limma based multiple linear regressions were performed for abundance and expression comparisons between senescence high and low groups. A p < 0.05 was considered as statistical significance