Table 4 Impact of CaGe treatment on the expression of hallmark genes of resistance/sensitivity to immune checkpoint inhibitors
From: Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy
Genes | Log2 fold change | P value | Adjusted p value |
|---|---|---|---|
NECTIN4 | 4.66 | 3.35e-22 | 1.06E-19 |
CD274 | 2.87 | 1.60e-20 | 4.36E-18 |
HMGB1 | −0.92 | 1.74e-08 | 7.04E-07 |
TNFSF18 | −2.83 | 0.0001 | 0.0015 |
B2M | −0.36 | 0.0036 | 0.026 |
TNFSF4 | −0.73 | 0.012 | 0.072 |
HLA-E | −0.35 | 0.039 | 0.16 |
PVR | 0.86 | 0.060 | 0.21 |
NT5E | 0.51 | 0.078 | 0.25 |
HLA-A | −0.64 | 0.10 | 0.31 |
HLA-C | −0.21 | 0.20 | 0.46 |
SELPLG | 0.52 | 0.25 | 0.53 |
CD47 | 0.35 | 0.27 | 0.54 |
NECTIN2 | −0.20 | 0.40 | 0.67 |
CD276 | 0.28 | 0.47 | 0.73 |
ICOSLG | 0.58 | 0.50 | 0.75 |
HLA-B | −0.10 | 0.52 | 0.76 |
NECTIN3 | 0.15 | 0.68 | 0.86 |
TNFSF14 | 1.01 | 0.31 | NA |
CEACAM1 | 1.04 | 0.45 | NA |