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Table 1 Baseline characteristics of all patients, BPA responders and non-responders

From: Effects of right ventricular remodeling in chronic thromboembolic pulmonary hypertension on the outcomes of balloon pulmonary angioplasty: a 2D-speckle tracking echocardiography study

Variables

All patients (n = 76)

Responders (n = 56)

Non-responders (n = 20)

P-value

Demographics

 Age, years

59.5 (16.0)

58.2 ± 10.9

55.2 ± 14.4

0.341

 Female, n (%)

51 (67.1)

38 (67.9)

13 (65.0)

0.815

 BSA, cm2

1.7 (0.2)

1.7 ± 0.1

1.7 (0.3)

0.706

Echocardiography

 PASP, mmHg

86.9 ± 20.5

84.3 ± 21.1

94.1 ± 17.0

0.066

 TAPSE, mm

14.8 ± 3.3

15.3 ± 3.3

13.4 ± 2.8

0.030

 LVEI

1.3 (0.2)

1.3 (0.2)

1.5 ± 0.2

0.029

 TRV, cm/s

433 ± 58.1

425.9 ± 59.9

456.0 ± 47.2

0.046

 DIVC, mm

22.4 ± 4.7

22.0 ± 4.8

23.7 ± 4.1

0.164

 S', cm/s

9.1 (2.5)

9.1 (3.0)

9.1 (1.5)

0.729

 RIMP

0.8 (0.3)

0.7 (0.3)

0.8 (0.2)

0.051

 FAC, %

29.4 ± 9.9

30.8 ± 9.9

25.7 ± 9.2

0.050

 RVEDA, cm2

25.3 ± 7.2

23.9 ± 6.9

29.1 ± 6.9

0.006

 RVESA, cm2

18.2 ± 6.8

16.9 ± 6.4

21.8 ± 6.6

0.006

 RV basal diameter, mm

45.9 ± 6.9

45.0 ± 6.7

47.5 (7.5)

0.119

 DMPA, mm

32.0 (6.2)

31.0 (6.2)

33.2 (7.0)

0.296

 DRPA, mm

24.0 (4.4)

23.0 (4.5)

24.9 ± 3.8

0.174

 DLPA, mm

22.0 (4.0)

21.6 (3.4)

22.9 ± 3.8

0.225

 LVEF, %

65.2 ± 5.1

65.0 ± 5.5

66.0 ± 3.9

0.456

Strain parameters

 STE-RVFWLS, %

15.7 (7.6)

16.7 (6.1)

10.0 (2.3)

 < 0.001

 STE-RVGLS, %

13.4 ± 4.4

14.1 (5.6)

8.7 (2.6)

 < 0.001

Hemodynamics

 CVP, mmHg

8.1 ± 4.1

6.5 (5.0)

9.0 ± 3.2

0.154

 mPAP, mmHg

50.8 ± 10.4

50.3 ± 10.5

52.1 ± 10.3

0.547

 PVR, dyn·s·cm−5

888.7 ± 363.5

879.6 ± 373.2

914.4 ± 342.8

0.528

 PCWP, mmHg

9.0 (5.5)

9.0 (6.0)

10.0 (8.0)

0.426

 CO, L/min

3.9 (1.4)

4.1 ± 1.1

3.9 ± 1.3

0.640

 CI, L/min/m2

2.3 ± 0.5

2.3 ± 0.5

2.2 ± 0.5

0.564

Clinical indicators

 WHO FC

  I/II/III/IV

4/40/29/3

2/35/16/1

2/5/13/2

0.001

  6WMD, m

385.5 (126.0)

393.0 (104.0)

312.0 (232.5)

0.019

  NT-proBNP, ng/L

675.0 (1858.0)

542 (1214.0)

1647 (2441.8)

0.011

BPA procedures

 Number of BPA sessions

5 (3)

5 ± 2

4 ± 2

0.465

 Time Interval, days

331.0 (446.0)

331.0 (472.3)

334.5 (439.0)

0.986

  1. Values are expressed as mean ± SD, median (IQR), or frequency (percentage), as appropriate
  2. Abbreviations: BSA Body surface area, PASP Pulmonary artery systolic pressure by echocardiography, TAPSE Tricuspid annular plane systolic excursion, LVEI Left ventricular eccentric index, TRV Tricuspid regurgitation peak velocity, DIVC Diameter of inferior vena cava; S', peak systolic velocity of the tricuspid annulus, RIMP Right ventricular index of myocardial performance, FAC Right ventricular fractional area change, RVEDA RV end-diastolic area, RVESA RV end-systolic area, DMPA Main pulmonary artery diameter, DRPA Right pulmonary artery diameter, DLPA Left pulmonary artery diameter, LVEF Left ventricle ejection fraction, STE-RVFWLS Speckle tracking echocardiography-RV free wall longitudinal strain, STE-RVGLS Speckle tracking echocardiography-RV global longitudinal strain, CVP Central venous pressure; mPAP, mean pulmonary artery pressure, PVR Pulmonary vascular resistance, PCWP Pulmonary capillary wedge pressure, CO Cardiac output, CI Cardiac index, WHO FC World Health Organization Functional Class, 6MWD 6 min walking distance, NT-proBNP N-terminal probrain natriuretic peptide, BPA Balloon pulmonary angioplasty