Table 1 Inhalant LPS-induced lung inflammatory responses are not reduced in CCR2 knock-out (KO) mice

BALF cells (× 10 ⁵ )

 Total Cells

0.85 ± 0.4

0.96 ± 0.24

16.45 ± 6.39^#

28.47 ± 19.77^#

 Neutrophils

0.42 ± 0.19

0.42 ± 0.23

9.71 ± 3.38^#

17.35 ± 12.46^#

 Mɸ

0.78 ± 0.39

0.84 ± 0.19

3.11 ± 1.62

3.45 ± 1.56

 Lymphocytes

0.04 ± 0.07

0.02 ± 0.04

0.09 ± 0.14

0.08 ± 0.12

Lung cells (× 10 ⁵)

 Total cells

8.69 ± 3.01

7.86 ± 1.99

33.08 ± 7.41^#

43.05 ± 15.18^#

 Neutrophils

0.42 ± 0.19

0.48 ± 0.25

8.48 ± 2.47^#

18.94 ± 9.22 ^#,*

 Alveolar Mɸ

2.01 ± 0.88

3.26 ± 1.61

0.35 ± 0.25^#

0.30 ± 0.24^#

 Activated Mɸ

0.15 ± 0.09

0.22 ± 0.08

2.27 ± 0.34^#

1.91 ± 0.45^#

 Monocyte-Mɸ

0.34 ± 0.15

0.27 ± 0.15

4.77 ± 1.9^#

2.20 ± 0.82 ^#,*

 Monocytes

0.28 ± 0.06

0.20 ± 0.10

1.51 ± 0.57^#

1.13 ± 0.77^#

 CD19⁺ B cells

2.14 ± 0.74

1.81 ± 0.53

4.81 ± 1.08^#

5.01 ± 0.78^#

 CD4⁺ T cells

0.98 ± 0.38

0.60 ± 0.18

2.44 ± 0.85^#

2.66 ± 0.82^#

 CD8⁺ T cells

0.94 ± 0.41

0.69 ± 0.23

3.08 ± 0.99^#

3.43 ± 0.91^#

 NK Cells

0.94 ± 0.41

0.66 ± 0.25

2.95 ± 1.04^#

2.52 ± 1.00^#

Lung Mediators

 TNF-⍺ (pg/ml)

1.54 ± 2.22

0.00 ± 0.00

26.52 ± 13.66^#

33.54 ± 27.50^#

 IL-6 (pg/ml)

3.00 ± 1.88

3.90 ± 2.34

67.26 ± 37.0^#

77.41 ± 56.05^#

 CXCL1 (pg/ml)

37.60 ± 27.99

55.3 ± 58.27

642.8 ± 274.7^#

799.8 ± 186^#

 MMP-3 (ng/ml)

5.08 ± 1.69

4.70 ± 1.00

61.85 ± 35.15^#

77.91 ± 33.05^#

 MMP-8 (ng/ml)

26.74 ± 7.45

21.97 ± 17.59

102.69 ± 36.01^#

117.49 ± 57.75^#

 TIMP-1 (ng/ml)

1.15 ± 0.73

2.39 ± 2.58

30.16 ± 10.21^#

27.70 ± 15.36^#

 CCL2 (pg/ml)

31.59 ± 7.62

134.7 ± 74.02

707 ± 65^#

1730 ± 840 ^#,*

 CCL7 (pg/ml)

21.21 ± 9.16

62.87 ± 32.28

1652 ± 420.7^#

3655 ± 1662^#

Serum

 CCL2 (pg/ml)

36.4 ± 23.0

141.4 ± 35.9

52.09 ± 18.2

250 ± 108 ^#*

 CCL7 (pg/ml)

101.4 ± 27.4

3420 ± 908.5 ^#

141.1 ± 56.4

5530 ± 1129 ^#*