Fig. 5
From: Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease
The correlation between the airway microbiome functional modules and its genetically associated host genes at the transcriptomic level in COPD patients. Regional manhattan plots on the left show the associations between three KEGG modules (M00332, M00542, M00375, a-c with the host genetic variants in PARK7 and NARS2. The mapped genes are marked in red and the top lead SNP is colored in purple. The red line represents the P-value of 1.0 × 10−5. Scatterplots in the middle show the significant correlation of the three KEGG modules (x-axis) and the expression of host genes PARK7 and NARS2 (y-axis). The plots on the right show the corresponding genetic loci from SMR analysis. The gray dots in the top mannattan plots show P-values for SNPs associated with KEGG modules. The bottom plots represent the eQTL P-values of SNPs from the GTEx study for probe ENSG00000116288 tagging PARK7 and ENSG00000137513 tagging NARS2. The genes (PARK7 and NARS2) that passed SMR and HEIDI tests are highlighted in red