From: Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease
Microbiome taxa and modules | SNP | Chr | Major allele | Minor allele | P-value | Gene | Spearman P-value | FDR | Rho |
---|---|---|---|---|---|---|---|---|---|
Veillonella parvula | rs62442525 | 7 | G | A | 3.20E-06 | NUDT1 | 1.11E-06 | 1.26E-04* | 0.483 |
Veillonella parvula | rs62442525 | 7 | G | A | 3.20E-06 | MAD1L1 | 7.59E-05 | 2.72E-03* | 0.401 |
Stenotrophomonas maltophilia | rs9967912 | 20 | A | C | 4.00E-06 | TTLL9 | 1.80E-04 | 3.08E-03* | 0.402 |
Treponema denticola | rs6568956 | 6 | A | C | 5.46E-06 | RWDD1 | 3.67E-04 | 7.76E-03* | 0.371 |
Rothia mucilaginosa | rs79257400 | 1 | C | G | 1.90E-06 | MAST2 | 1.52E-03 | 8.35E-03* | 0.331 |
Prevotella intermedia | rs7204848 | 16 | A | G | 9.14E-07 | BCAR1 | 1.17E-03 | 5.73E-02 | 0.335 |
Haemophilus influenzae | rs56396137 | 12 | A | G | 2.09E-06 | LTA4H | 6.76E-03 | 6.21E-02 | 0.304 |
Haemophilus influenzae | rs4352337 | 3 | G | A | 5.03E-06 | KBTBD12 | 8.91E-03 | 7.20E-02 | 0.294 |
Campylobacter concisus | rs4683647 | 3 | C | T | 6.00E-06 | ATP1B3 | 1.11E-02 | 7.84E-01 | 0.265 |
Neisseria mucosa | rs6557999 | 8 | A | G | 8.85E-06 | PTK2B | 1.99E-02 | 8.05E-01 | −0.246 |
Streptococcus salivarius | rs6917641 | 6 | A | G | 9.54E-08 | TBC1D32 | 3.57E-02 | 8.60E-01 | 0.228 |
Streptococcus pneumoniae | rs147224807 | 5 | T | G | 4.13E-06 | AFF4 | 2.95E-02 | 8.89E-01 | −0.242 |
Treponema denticola | rs6568956 | 6 | A | C | 5.46E-06 | RSPH4A | 3.91E-02 | 4.75E-01 | 0.220 |
Xanthomonas euvesicatoria | rs111818593 | 12 | A | G | 2.54E-06 | MRPS35 | 3.13E-02 | 3.84E-01 | −0.234 |
Ralstonia insidiosa | rs34568075 | 6 | A | – | 3.70E-06 | TBC1D32 | 3.82E-02 | 9.14E-01 | 0.224 |
M00542: EHEC/EPEC pathogenicity signature | rs34823376 | 1 | G | A | 4.70E-06 | ERRFI1 | 5.75E-03 | 2.03E-02* | −0.289 |
M00044: Tyrosine degradation | rs12311799 | 12 | G | A | 8.18E-06 | KLHL42 | 5.17E-03 | 2.65E-02* | 0.289 |
M00542: EHEC/EPEC pathogenicity signature | rs34823376 | 1 | G | A | 4.70E-06 | PARK7 | 8.25E-03 | 3.14E-02* | −0.277 |
M00375: Hydroxypropionate-hydroxybutylate cycle | rs150193199 | 11 | G | C | 9.19E-06 | NARS2 | 3.08E-03 | 4.67E-02* | −0.317 |
M00338: Cysteine biosynthesis | rs545977123 | 11 | G | C | 1.38E-06 | EPS8L2 | 7.78E-03 | 5.54E-02 | −0.28 |
M00332: Type III secretion system | rs34823376 | 1 | G | A | 6.20E-06 | ERRFI1 | 3.14E-03 | 5.98E-02 | −0.31 |
M00218: Fructose transport system | rs17121175 | 1 | C | A | 9.00E-06 | NFIA | 2.56E-02 | 9.02E-02 | −0.234 |
M00332: Type III secretion system | rs34823376 | 1 | G | A | 6.20E-06 | PARK7 | 6.98E-03 | 9.86E-02 | −0.284 |
M00512: CckA-CtrA/CpdR (cell cycle control) two-component regulatory system | rs17824678 | 12 | G | A | 4.63E-06 | MSRB3 | 2.30E-02 | 1.19E-01 | 0.244 |
P02010: ABC transporters | rs146351733 | 11 | A | – | 4.04E-06 | PDGFD | 4.00E-02 | 1.63E-01 | −0.215 |
M00540: Benzoate degradation | rs1741618 | 20 | T | A | 4.35E-06 | EEF1A2 | 4.33E-02 | 3.71E-01 | −0.215 |
M00511: PleC-PleD (cell fate control) two-component regulatory system | rs5746415 | 22 | A | G | 2.86E-07 | CECR2 | 2.78E-02 | 5.10E-01 | −0.236 |