Fig. 10
From: TFEB regulates dendritic cell antigen presentation to modulate immune balance in asthma
Schematic representation of knockdown of TFEB regulating Th0 cell subpopulation differentiation through inhibition of dendritic cell antigen presentation. The suppression of TFEB hindered the migratory ability of dendritic cells and reduced the surface expression of CD40, CD80, CD86, and MHC-II on DC cells, thereby impacting the differentiation of Th0 cell subtypes. This inhibition led to decreased expression of pro-inflammatory factors and increased expression of anti-inflammatory factors, ultimately rebalancing the Th1/Th2 and Treg/Th17 cell equilibrium