Fig. 2

EccDNAs co-expression in IPAH patients and healthy participants and differentially expressed eccDNA genes. A The total number of eccDNAs expressed in IPAH patients and healthy participants was 21,741. B Dispersion maps of differentially expressed eccDNAs in the IPAH and Control groups. Red dots indicate upregulation, green dots indicate downregulation, and the default multiplicative change threshold was 2.0. C Volcano plots were plotted using the fold change and P-value when comparing the samples. Red rectangles represent differentially expressed eccDNAs. D Heat map and hierarchical clustering of eccDNAs