Fig. 4

Expression levels of eccDNAs in patients with PAH and control participants. A-B Expression levels of two selected eccDNAs in patients with IPAH and control participants in the discovery group (patients, n = 3; controls, n = 3). C-D Expression of eccDNA-chr2:131208878–131,424,362 and eccDNA-chr16:1771689–1,771,839 in patients with PAH and control participants in the validation group (patients, n = 30; controls, n = 10). E The ability of serum eccDNA-chr2:131208878–131,424,362 level to diagnose PAH was assessed using receiver operating characteristic curve analysis