Skip to main content

Table 1 Baseline characteristics of patients with PAH and healthy control subjects

From: Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in pulmonary arterial hypertension

Characteristics

Control subjects (n = 10)

PAH patients

(n = 30)

P value

Age (years), mean ± sd

51.6 ± 6.1319

47.633 ± 15.865

0.262

Sex, n (%)

  

0.690

Female

6 (60%)

22 (73.33%)

 

Male

4 (40%)

8 (26.67%)

 

HR (beats/min), median (IQR)

70 (66, 78.5)

69 (65.25, 75.25)

0.790

BMI (kg/m2), median (IQR)

21.955 (21.332, 23.125)

22.02 (20.755, 24.703)

0.938

NYHA class, n (%)

  

N/A

I - II

N/A

7 (23.33%)

 

III - IV

N/A

23 (76.67%)

 

6MWD (m), median (IQR)

 

175 (116.25, 242.5)

N/A

Hemodynamic

   

mPAP (mmHg), median (IQR)

N/A

67 (48.5, 73)

N/A

PCWP (mmHg), median (IQR)

N/A

9 (7, 11.75)

N/A

PVR (wood units), mean ± sd

N/A

9.6287 ± 5.605

N/A

CI (L/min/m2), median (IQR)

N/A

2.4 (2.2, 2.875)

N/A

Biochemical markers

   

NT-proBNP (pg/mL), median (IQR)

38 (33.25, 55.25)

1160 (491, 2377.5)

< 0.001

Troponin I (ng/mL), median (IQR)

0.018 (0.01525, 0.0205)

0.0165 (0.007275, 0.0215)

0.435

D-dimer (ug/L), median (IQR)

347 (317.25, 461.75)

583 (262, 895.25)

0.246

Total bilirubin (µmol/L), median (IQR)

13.65 (10.8, 15.425)

11.85 (9.275, 17.275)

0.864

ALT (U/L), median (IQR)

18 (12.75, 22.5)

11 (9, 22)

0.324

AST (U/L), median (IQR)

25.5 (21.25, 26.75)

20 (16, 23)

0.054

Triglyceride (mmol/L), median (IQR)

1.485 (0.965, 1.7475)

1.155 (0.8625, 1.47)

0.281

High-density lipoprotein (mmol/L), mean ± sd

2.512 ± 1.0959

1.284 ± 0.46964

0.006

Low-density lipoprotein (mmol/L), mean ± sd

1.467 ± 0.52915

1.7763 ± 0.43843

0.074

BUN (mmol/L), median (IQR)

4.65 (3.525, 5.55)

4.95 (3.725, 5.775)

0.790

Cr (umol/L), median (IQR)

61 (50.5, 77)

59.5 (48.5, 74)

0.650

UA (umol/L), mean ± sd

214 ± 57.329

438.87 ± 137.41

< 0.001

Echocardiography

   

LVEF (%), median (IQR)

77.5 (75.25, 79.5)

71 (65.25, 77.75)

0.063

Right atrial diameters (mm), mean ± sd

34.4 ± 4.4272

33.9 ± 3.0212

0.690

Right ventricular diameters (mm), median (IQR)

31.5 (30, 32)

36 (34.25, 38.75)

< 0.001

Left atrial diameters (mm), mean ± sd

31.6 ± 3.2387

29.967 ± 3.3578

0.187

Left-ventricular end-diastolic diameter (mm), mean ± sd

36.8 ± 2.044

35.733 ± 3.8141

0.406

Pulmonary artery diameter (mm), mean ± sd

28.2 ± 3.2592

29.345 ± 2.3188

0.234

Mitral orifice flow velocity (m/s), mean ± sd

0.83 ± 0.19465

0.77433 ± 0.23485

0.504

Aortic orifice velocity (m/s), median (IQR)

1.45 (1.1875, 1.575)

1.4 (1.2, 1.6)

0.962

Pulmonary valvular orifice velocity(m/s), mean ± sd

1.2 ± 0.27889

1.145 ± 0.21043

0.514

  1. Definition of abbreviations: HR = heart rate; BMI = body mass index; NYHA = New York Heart Association; 6MWD = 6-minute-walk distance; mPAP = mean pulmonary arterial pressure; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; CI = cardiac index; NT-proBNP = N-terminal pro–brain natriuretic peptide; ALT = alanine aminotransferase; AST = aspartate aminotransferase; BUN = blood urea nitrogen; Cr = creatinine; UA = uric acid; LVEF = left ventricular ejection fraction; N/A = not applicable
Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us