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Fig. 4 | Respiratory Research

Fig. 4

From: Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension

Fig. 4

Removal of NETs in rats can inhibit the ILK/β-parvin/RAC1 pathway to relieve PAH. (A) Disrupting NETs can alleviate weight loss caused by MCT. (B) Disruption of NETs can alleviate right ventricular hypertrophy index caused by MCT. (C) Concentrations of cf-DNA in rats peripheral blood serum. (D) Disruption of NETs can alleviate pulmonary artery thickening caused by MCT. (E) Western blotting analysis of proliferation related PCNA in pulmonary tissue. (F) Western blotting analysis of NETs-related PADI4 and MPO in pulmonary tissue. (G) Statistical plot of PCNA western blotting results. (H) Statistical plot of NETs-related PADI4 and MPO western blotting results. (I-J) Western blotting analysis of CCDC25, and ILK/β-parvin/RAC1 pathway in pulmonary tissue. Protein levels were normalized to β-actin. All results were presented as the mean ± SEM (n = 3). The p values were determined by Student’s t-test. NS: p > 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001

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Respiratory Research

ISSN: 1465-993X

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