Fig. 1

Lipid accumulation was obviously found in AECIIs in mice lung fibrosis. A The scheme establishment of mouse lung fibrosis model. B, C, HE staining and Hydroxyproline content confirmed the mice lung fibrosis model, scale bar = 50 μm. D, Oil red staining showed significant lipid accumulation in mice lung fibrosis section arrow indicate the positive cells, scale bar = 50 μm. E, In vitro oil red staining showed that upon Bleomycin injury, dramatic lipid accumulation was only found in lung alveolar epithelial cells rather than lung fibroblast, scale bar = 20 μm. F, Nile red and SFTPC co-staining indicated the lipid was observed specifically in AECIIs, arrow indicate the SFTPC positive cells, scale bar = 20 μm. Data are expressed as mean ± SD, *: p < 0.05; **: p < 0.01