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Fig. 3 | Respiratory Research

Fig. 3

From: Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

Fig. 3

HMGCS2 was down regulated in IPF patients and associated with lung function. A, HMGCS2 was significantly down regulated in IPF patients (N = 254) compared with healthy individuals (N = 108) (GES47460). B, The expression pattern of HMGCS2 was further confirmed in IPF lung sections (Normal looking alveolar area VS dense fibrotic region), scale bar = 20 μm. C, HMGCS2 expression was positively correlated with lung function in IPF cohort (GES47460) (DLCO, R = 0.44, P < 0.01), forced expiratory volume (FEV, R = 0.23, P < 0.01), and forced vital capacity (FVC, R = 0.30, P < 0.01), Data are expressed as mean ± SD, *: p < 0.05; **: p < 0.01

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Respiratory Research

ISSN: 1465-993X

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